An elevated serum urate level, together with local factors, can result in the deposition of urate crystals into the joints. Once crystals are deposited into a joint, they can be released into the joint space and initiate an inflammatory cascade causing acute gouty arthritis. These acute flares resolve, but the crystals remain in the joint.
The study uses data from the FDA. It is based on diclofenac potassium and ibuprofen (the active ingredients of Diclofenac potassium and Ibuprofen, respectively), and Diclofenac potassium and Ibuprofen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Can I take diclofenac and ibuprofen? No. Diclofenac and ibuprofen should not be taken together since they work in a similar way. Taking them together can increase the risk of adverse events and side effects. Antibiotics. If you are taking methotrexate, you should completely avoid taking any antibiotic that contains trimethoprim-sulfa, such as Bactrim, Sulfatrim, and Septra. Adverse effects are caused by the antibiotic's ability to reduce methotrexate absorption in the body. When the absorption rate is slowed, it can lead to a buildup of the yfmzy.